"The previous 'Alien' movie and last 'Predator' movie were seen as real disappointments so I think 'AvP' did kind of reenergize everything," he explained. "In the 'Underworld' and 'Resident Evil' world, both of those franchise are quite vibrant and healthy so the idea of a crossover is probably too premature."
He added: "Knowing Kate [Beckinsale] and Milla [Jovovich], I'm sure they would love to work together and maybe that will happen, but I doubt that kind of crossover would occur."
"Underworld" director Len Wiseman also provided an opinion. "What's funny is that they're very similar, both at Screen Gems, both husband-wife teams and both on the same number right now. We joke about it a lot, Paul and I, but I don't know. I as a fan would love to see it, but it would have to make sense within both worlds."
Source: http://www.shocktillyoudrop.com/news/16 ... cross-over